منابع مشابه
Pain with donepezil.
An 85-year-old lady with a 4-year history of Alzheimer's dementia was started on a dose of 5 mg of Donepezil. Improvements were noted in her overall mental state with an associated reduction in the level of carer stress but with mild and transient subjective gastrointestinal complaints. Therefore, the dose was cautiously increased to 10 mg. But within 10 days of the increase, she reported bilat...
متن کاملDonepezil reverses intermittent stress-induced generalized chronic pain syndrome in mice.
Treatment of fibromyalgia is an unmet medical need. To develop novel therapies for the treatment of fibromyalgia, we explored pain therapeutic actions of existing pharmaceuticals, which inhibit the somatic symptoms frequently observed in fibromyalgia patients. This study first examined the therapeutic actions of pilocarpine, which inhibits dry-eye and dry-mouth symptoms, using an experimental f...
متن کاملEffects of Nano-Chitosan Loaded with Donepezil on Ethanol Induced Amnesia in Swiss-type Mice
Background: Progressive neurodegeneration of nervous system as well as learning and memory disorders is characteristics of Alzheimer’s disease. Drug delivery is one of the research aspects for improving treatment of diseases. Chitosan nanoparticles were used for Donepezil transportation and its effect on dimproving amnesia was investigated. Materials and Methods: In this experimental study, 13...
متن کاملUpdate on Alzheimer drugs (donepezil).
BACKGROUND Several clinical trials have been conducted over a period of many years reporting the benefits of donepezil for Alzheimer disease (AD) patients. REVIEW SUMMARY Randomized, double-blind, placebo-controlled stud-ies of 3-6 months' duration have demonstrated significant benefits for 5mg/D and 10 mg/D of donepezil compared with placebo. The results include benefits for cognition, activ...
متن کاملCardiac safety of donepezil in elderly patients with Alzheimer disease.
OBJECTIVE Donepezil is a widely used cholinesterase inhibitor for the treatment of Alzheimer's disease (AD), however its cholinergic adverse side effects on the cardiovascular system are still unclear. In this study, we aimed to examine the adverse side effects caused by donepezil on cardiac rhythm and postural blood pressure changes in elderly patients with Alzheimer Disease. METHODS The ECG...
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ژورنال
عنوان ژورنال: Age and Ageing
سال: 2006
ISSN: 1468-2834,0002-0729
DOI: 10.1093/ageing/afl090